Figure 1: Microglia-released ASC specks bind to and cross-seed β-amyloid peptides. Figure 2: ASC specks co-sediment with Aβ and form the core of mouse and human Aβ plaques. Figure 3: Asc knockout ...

Publication showed that IC 100 suppressed retinal microglia activation by interfering with ASC speck formation, attenuating retinal inflammation, abnormal retinal vascularization, and retinal thinning ...