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生物通
9月
基于 c-MYC 启动子序列的 Pu22 G - 四链体与抗肿瘤吖啶衍生物的相互 ...
本文通过光谱和计算分析,研究了 c-MYC NHE III 1 代表性 G - 四链体 Pu22 与两种有前景的双吖啶(C-2045、C-2053)及其单体(C-1311、C-1748)的相互作用机制,为以 c-MYC 为靶点的治疗药物开发提供了重要依据。 ### 引言 不对称双吖啶(UAs)是一类新型抗癌化合物,对 ...
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