Non-coding DNA variants contribute to acute lymphoblastic leukemia (ALL) chemotherapy resistance. St. Jude Children's Research Hospital scientists have identified specific DNA variants in the ...

(L to R) Co-first author Jackson Mobley, PhD, corresponding author Daniel Savic, PhD, and co-first author Kashi Raj Bhattarai, PhD, all of the St. Jude Department of Pharmacy and Pharmaceutical ...

Around 98.5% of human DNA is non-coding, meaning it doesn’t get copied to make proteins. A new study has connected many of these non-coding regions to the genes they affect and laid out guidelines for ...

Researchers announced a significant paradigm shift in the understanding of T-lineage acute lymphoblastic leukemia (T-ALL), an aggressive and high-risk form of cancer, to one frequently driven by ...

The non-coding genome, once referred to as "junk DNA," is now understood to be a fundamental regulator of gene expression and a key factor in understanding complex diseases. Image credit: ...

Only around two percent of the human genome codes for proteins, and while those proteins carry out many important functions of the cell, the rest of the genome cannot be ignored. However, for decades ...

Researchers have revealed that so-called ‘junk DNA’ contains powerful switches that help control brain cells linked to Alzheimer’s disease. When people picture DNA, they often imagine a set of genes ...

Long non-coding RNAs exist in the so-called "Wild West" (99%) of the human genome that is currently understudied. Not only does this finding have treatment implications for patients with ...

For decades, scientists have been puzzled by large portions of the human genome labeled as “junk” DNA, sequences that seemingly serve no purpose. Yet, recent studies suggest these cryptic sequences ...