在这项研究中，研究人员表明，DNA断裂在修复后的基因组位点上留下了长期的标记，这破坏了大染色质邻域的三维排列，持续了几轮连续的细胞分裂，并引发了基因表达的遗传性改变，即使原发性DNA损伤被完全修复。该研究将这种现象称为染色质疲劳，并提出它代表了迄今为 ...

When people think of DNA, they visualize a string-like double helix structure. In reality, the DNA double helix in cells is supercoiled and constrained into loops. This supercoiling and looping are ...

It has been claimed that because most of our DNA is active, it must be important, but now human-plant hybrid cells have been ...

Research reveals that five DNA letters can switch chromatin between fluid and solid-like states, influencing gene ...

When people think of DNA, they visualize a string-like double helix structure. In reality, the DNA double helix in cells is supercoiled and constrained into loops. This supercoiling and looping are ...

A team of physicists working at the intersection of theory and experiment are shedding new light on the 'teamwork' of molecular motors -- called RNA polymerases (RNAPs) -- that mediate DNA ...

Researchers have discovered how cells activate a last-resort DNA repair system when severe damage strikes. When genetic ...

The protein complex that holds strands of DNA in compact spools partially disassembles itself to help genes reveal themselves to specialized proteins and enzymes for activation, according to Rice ...

One of the most detailed 3D maps of how the human chromosomes are organized and folded within a cell's nucleus is published ...

The expression pattern of a single gene or multiple genes can be investigated using a technique RNA microarray. In this technique, RNA molecules are ‘spotted’ onto a solid surface. These act as probes ...