Studies on diseases that affect the human brain are usually based on animal models which cannot reproduce the complexity of human neuropathies. Therefore, these methodologies often fail when applied ...

Researchers have identified key factors that promote the reprogramming of human stem cells to the naïve state, which can be used to model the earliest stages of development. This new knowledge will ...

Scientists report that they have used a cellular reprogramming methodology to allow the creation of neural networks that reproduce unique characteristics of human cells—different from those obtained ...

Mammalian hearts have almost no ability to grow new heart muscle cells, called cardiomyocytes, after birth. Thus, dead tissue after an adult heart attack is not repaired with new cardiomyocytes. It is ...

Scientists have produced stem cells from the endangered Grévy's zebra using human reprogramming factors. Further comprehensive gene analyses identified key genes that are also found in human and mouse ...

Scientists from Kyoto University’s Institute for Integrated Cell-Material Sciences (iCeMS) and Wildlife Research Centre have produced stem cells from the endangered Grévy’s zebra using human ...

Background Intestinal fibrosis, a hallmark complication of Crohn’s disease (CD), frequently progresses to stricture formation ...