This figure shows primary T cells modified using two approaches. CAR receptors are introduced through targeted DNA insertion (top), while CRISPRoff mRNA and guide RNAs silence additional genes through ...

The Notch signaling pathway plays a pivotal role in determining cell fate, especially in the development and function of T cells. But mimicking this highly mechanical, contact-dependent pathway in the ...

A new paper published today in Cell highlights how researchers have leveraged AI-based computational protein design to create a novel synthetic ligand that activates the Notch signaling pathway, a key ...

"T cells' capability to fully prevent acute viral infections opens new avenues for vaccine development." ScienceDaily. www.sciencedaily.com / releases / 2025 / 01 / 250110121913.htm (accessed December ...

Researchers have developed a new stem cell model of the mature human amniotic sac, which replicates development of the tissues supporting the embryo from two to four weeks after fertilization. This is ...

Human “bodyoids” could reduce animal testing, improve drug development, and alleviate organ shortages. Why do we hear about medical breakthroughs in mice, but rarely see them translate into cures for ...