This is a preview. Log in through your library . Abstract We consider the problem of maximum-likelihood estimation in case-control studies of gene-environment associations with disease when genetic ...

We consider estimation of mixed-effects logistic regression models for longitudinal data when missing outcomes are not missing at random. A typology of missingness mechanisms is presented that ...

Modern statistical modelling is increasingly focused on reducing bias and enhancing the accuracy of parameter estimates. Traditional maximum likelihood estimation, while powerful, can encounter ...