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9 天
Zebra_K+:在神经毒性测试中,对斑马鱼胚胎和幼体听觉惊跳反应可塑 ...
本研究开发并验证了Zebra_K?平台,可高通量分析斑马鱼胚胎(5 dpf)和早期幼虫(6-7 dpf)的听觉惊吓反应(ASR)动力学、敏感性和短时习惯化,以及预备脉冲抑制(PPI)。通过使用NMDA受体拮抗剂、多巴胺受体激动剂和D2受体拮抗剂,验证了该平台在神经毒理学和 ...
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