NASHVILLE, Tenn. -- Racial biases persist in the use of pulse oximetry devices for patients with acute hypoxemic respiratory failure (AHRF) requiring very high levels of oxygen support, a ...

Cytokinetics has revealed the results from a phase 3 trial of its hypertrophic cardiomyopathy (HCM) drug aficamten that it hopes will allow it to compete with Bristol-Myers Squibb’s first-to-market ...

Correspondence to Dr Hideo Ohuchi, Department of Paediatric Cardiology, National Cerebral and Cardiovascular Centre, 5-7-1, Fujishiro-dai, Suita, Osaka 565-8565, Japan; hohuchi{at}hsp.ncvc.go.jp ...

Definitions of hypoxaemia, hypoxia, type 1 respiratory failure and hyperoxaemia Definition of hypercapnia and type 2 respiratory failure Definition of acidosis (respiratory acidosis and metabolic ...

Introduction Identifying acute hypercapnic respiratory failure is crucial in the initial management of acute exacerbations of COPD. Guidelines recommend obtaining arterial blood samples but these are ...

Abstract: This paper proposes a novel mathematical model that quantitatively defines the relationships between the arterial oxygen saturation (SaO2), the arterial partial pressure of oxygen (PaO2) and ...

Under O 2-rich conditions, O 2 inhibits the growth of OA that lack the mechanisms to defend against ROS. This vulnerability arises because anaerobic metabolism relies on catalytic sites with ...

Abstract: The paper proposes the diagnosis of Sleep Apnea Hypopnea Syndrome (SAHS) only using snore sound and SaO2 signals. The time-frequency characteristics of snore sound signal are extracted to ...

Cytokinetics, Incorporated's (CYTK) shares surged 40.4% on Sept. 2, driven by positive results from a phase III study on cardiovascular candidate aficamten. On Aug. 30, Cytokinetics presented primary ...

Data from the late-stage MAPLE-HCM study position Cytokinetics’ cardiac myosin inhibitor aficamten as a potential first-line therapy for patients with obstructive hypertrophic cardiomyopathy.

来自国际研究团队的系统性综述揭示：心肺运动试验(CPET)能显著提升肥厚型心肌病(HCM)患者的心功能评估灵敏度。通过对12,914 ...

这篇研究通过分析Fontan循环患者运动时的峰值外周静脉压（PPVP）与峰值摄氧量（PVO2）关系，揭示了静脉-静脉侧支（VVCs）的双重作用：低PVO2时缓冲中心静脉压，高PVO2时加重静脉负荷，为临床评估VVCs的血流动力学影响提供了新视角。 Fontan手术的预后近年来因 ...